By Gert Lubec
A new promising animal version of DS is suggested and this opens new possibilities to check pathomechanisms and pharmacological ways because it is greater than tough to hold out reviews in people and the medical good points are hugely variable. when it comes to biology, phone cycle and stem phone experiences and by way of biochemistry, relevance of stories on a selected protein kinase, channels, transporters, superoxide dismutase, antioxidant process, chromosome meeting issue and different vital organic constructions are supplied. And back, the gene dosage speculation is addressed and even supposing the majority of chromosome 21 gene items is unchanged in fetal DS mind, a couple of particular chromosome 21 encoded buildings together with transcription elements are certainly overexpressed even if findings in fetal DS are diverse from these in grownup DS mind whilst Alzheimer-like neuropathology supervenes.
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Advances in Down Syndrome Research (Journal of Neural Transmission. Supplementa) by Gert Lubec